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A comparative study of topical versus intrastromal injection plus topical voriconazole for treatment of deep or resistant fungal keratitis

Poster Details

First Author: M.Tawfeek EGYPT

Co Author(s):    K. Soliman   A. Alkawas   B. Ibrahim        

Abstract Details

Purpose:

To compare the safety and efficacy of topical versus intrastromal injection plus topical voriconazole for treatment of deep and/or resistant fungal keratitis.

Setting:

A prospective, randomized study performed on eyes with deep and/or resistant fungal keratitis during the period from April 2011 to May 2013 in Zagazig university in Egypt. Only those patients with proven clinical and laboratory evidences of fungal keratitis (with smears and/or cultures) were included in the study.

Methods:

Each group included 20 eyes with deep and/or resistant fungal keratitis. The mean duration of follow up was a 12.75±2.31 weeks in group A and was 14.52±3.22 weeks in group B (P > 0.05). Complete healing and resolution of fungal keratitis was higher in group A (85 %) than in group B (55%) and the difference was statistically significant (P < 0.05). Laboratory studies showed increased prevalence of filamentous fungi (70 % in group A and 65 % in group B) more than yeasts (30 % in group A and 35 % in group B), and the difference between both groups was statistically not significant (P > 0.05).

Results:

Topical voriconazole, either intrastromal injection or eye drops, is a very effective, antifungal therapy for treatment of deep and/or recalcitrant fungal keratitis. Intrastromal injection hastens the resolution period for treatment of fungal keratitis and hence shortens the period of hospitalization.

Conclusions:

-

Financial Disclosure:

NONE

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