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Depth of corneal collagen crosslinking demarcation line according to different types of riboflavin solutions

Poster Details

First Author: B.Bozkurt TURKEY

Co Author(s):    A. Mesen   U. Kamis   B. Ekinci-Koktekir   S. Okudan     

Abstract Details

Purpose:

To compare the depth of corneal stromal demarcation line after corneal collagen crosslinking (CXL) according to different types of riboflavin solutions using anterior segment optical coherence tomography (OCT).

Setting:

University Hospital, Ophthalmology Department

Methods:

Thirty-three eyes of 27 patients (13 male, 14 female) with progressive keratoconus who underwent CXL treatment according to standard Dresden protocol within 1 year period were enrolled in the study. Isotonic riboflavin with dextran, without dextran and transepithelial (TE) riboflavin solutions were used in 18 eyes, 9 eyes and 6 eyes, respectively. Corneal demarcation line depth was measured centrally by 2 different operators (BB and AM) who were blind to riboflavin solutions and the treatment period using anterior segment OCT (Spectralis, Heidelberg Engineering, Germany).

Results:

Mean keratometric values (K1, K2) and central corneal thickness were 46.8+2.5 D, 51.1+3.1 D and 446+28.4 μm, respectively. Stromal demarcation line could be detected in 25 eyes (75.8%). Mean demarcation depth was 247.8+43.9 μm within a range of 179 and 358 μm. Mean depth was shallower in TE solution compared to isotonic riboflavin with and without dextran solution; however the difference was statistically insignificant (p>0.05). The time period after CXL treatment was statistically higher in eyes without a demarcation line (7.1+3.1 months) compared to eyes with a detactable demarcation line (3.2+1.7 months) (p<0.05).

Conclusions:

Anterior segment OCT is useful in detection of stromal demarcation line after CXL procedure, which is remarkable in the first 3 months period. Although the depth of demarcation line seems to be shallower in TE solutions compared to isotonic solutions with and without dextran, more prospective studies are needed for a statistical significance.

Financial Disclosure:

NONE

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