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Corneal biomechanical properties in patients with hashimoto thyroiditis

Poster Details

First Author: E.Baser TURKEY

Co Author(s):    E. Tiryaki   B. Ersoy   D. Kizilay        

Abstract Details

Purpose:

Autoimmune diseases can have impact on corneal physiology and behavior via changes in conjunctiva, tear film and cornea. Hashimoto thyroiditis (HT) is such an autoimmune disorder which is suspected to have effects on the cornea. This study was undertaken to investigate corneal biomechanical properties of pediatric patients with HT.

Setting:

Celal Bayar University School of Medicine, Departments of Ophthalmology and Pediatric Endocrinology.

Methods:

A total of 54 patients with HT were included in the study. Corneal biomechanical features consisting of corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with the Reichert Ocular Response Analyzer (ORA). Central corneal thickness (CCT) mesaurements were performed with ultrasonic pachymeter. Duration of HT disease, levels for thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), anti-thyroglobulin (anti-TG) and anti-thyroid peroxidase (anti-TPO) were recorded. Correlation between corneal parameters and hormone - antibody levels were analyzed statistically.

Results:

The mean age of patients was 14.5 years and the mean duration of disease was 43.7 months. 39.8 % were euthyroid, 19.6% had subclinical hypothyroism and 40.6% had hypothyroidism. Mean CTT, CH and CRF mesaurements were 555 microns, 11.4 mmHg and 11.6 mmHg in right eyes, and 554 microns, 10.8 mmHg and 11.1 mmHg in left eyes, respectively. Both CCT and corneal biomechanical parameters showed no signifant correlations with duration of disease and hormonal parameters (TSH, T3, T4, antiTG, antiTPO). Similarly, no significant association was found between corneal parameters and hormone replacement therapy or presence of hypothyroidism..

Conclusions:

Corneal biomechanical properties and CCT values do not seem to be influenced by autoimmune thyroid disease in pediatric patients.

Financial Disclosure:

NONE

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