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Anterior Segment Morphological Changes Related to Alpha-1 Adrenergic Receptor Antagonists Use

Poster Details

First Author: N.Yuksel TURKEY

Co Author(s):    M. Ozer   T. Takmaz   U. Ozen   M. Metin   E. Akcay  

Abstract Details

Purpose:

To investigate possible changes in anterior segment parameters with the Pentacam to predict intraoperative floppy eye syndrome in patients taking tamsulosin or doxazosin for benign prostatic hyperplasia.

Setting:

Necip Fazil City Hospital, Kahramanmaras Ankara Training and Research Hospital, Ankara

Methods:

In this prospective, cross-sectional study, patients were grouped as follows: 29 patients treated with tamsulosin (Group 1), 27 patients treated with doxazosin (Group 2) and 40 untreated controls (Group 3). Right eyes of each patient were included in the study. All patients underwent examination with the Pentacam under standard dim-light conditions and with undilated pupils. Anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, central corneal thickness (CCT), corneal volume (CV) and pupil diameter (PD) were recorded.

Results:

Mean duration of treatments were 2.7 ± 1.2 (1-5) and 2.4 ± 0.9 (1-5) years in Groups 1 and 2 (p= 0.276). ACD, ACV, ACA width and PD were statistically significantly decreased in Group 1 and 2 when compared to Group 3 (p < 0.05). There were no statistically significant differences among three groups in mean values of CCT and CV.

Conclusions:

In this study, decreased ACD, ACV, ACA width and PD values were detected in tamsulosin and doxazosin groups when compared to controls. These findings should be considered during anterior segment examinations and surgeries. To find a clue for IFIS with a reliable method is still required.

Financial Disclosure:

NONE

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