ISTANBUL escrs

Outcomes of corneal transplantation in Irish patients with congenital hereditary endothelial dystrophy (CHED)

Session Details

Session Title: Cornea
Session Date/Time: Sunday 22/02/2015 | 08:30-11:00
Paper Time: 09:24
Venue: Hall 2
First Author: : H.AlArrayedh IRELAND
Co Author(s): :    C. Murphy   L. Collum           

Abstract Details

Purpose:

To report the outcomes of corneal transplantation in Irish patients with congenital hereditary endothelial dystrophy (CHED).

Setting:

Royal Victoria Eye and Ear Hospital, Dublin, Ireland

Methods:

Records of all patients with CHED who underwent corneal transplantation at the Royal Victoria Eye and Ear Hospital in Dublin, from 1978 to 2013 were retrospectively reviewed. Patient demographics, preoperative and postoperative clinical data, visual acuity, graft survival, and graft clarity were analysed.

Results:

14 patients with CHED underwent transplantation. 33 corneal transplants were performed, 32 (PKPs) and 1 (DSEK). 24 primary grafts and 9 re-grafts, the graft survival rates at final follow-up were 37.5%, 33% respectively. At final post-operative visit, BCVA was 6/24 or better in 4 eyes following primary transplantation, 6/48 in 1 eye following re-grafting and 6/60 or worse in all other eyes. The mean time to graft failure was 16 months (0-37), and the mean follow-up time was 118 months (1-228). Graft survival with clear cornea at final follow-up was 36%. Only 50% of patients continue to attend for follow-up.

Conclusions:

The study has demonstrated a poor outcome from corneal transplantation for CHED in Irish patients relative to other indications. This arises from a combination of dense amblyopia and a high risk of graft failure in the long term.

Financial Disclosure:

NONE

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