ISTANBUL escrs

Early corneal biomechanical changes of three transepithelial corneal collagen crosslinking techniques in progressive keratoconus

Session Details

Session Title: Cornea
Session Date/Time: Sunday 22/02/2015 | 08:30-11:00
Paper Time: 08:48
Venue: Hall 2
First Author: : Q.Zeng CHINA
Co Author(s): :                  

Abstract Details

Purpose:

To evaluate early corneal biomechanical changes of three transepithelial corneal collagen crosslinking (TE-CXL) techniques in progressive keratoconus.

Setting:

Hankou Aier Eye Hospital, Wuhan, China

Methods:

Thirty keratoconus patients randomly divided into three groups were treated with three different TE-CXL techniques: application of a hypo-osmolar riboflavin solution (Ricrolin TE®) to the cornea for 30 minutes, riboflavin (Ricrolin+®) application by iontophoresis for 5 minutes, riboflavin (Ricrolin+®) application by iontophoresis for 10 minutes. Then the central cornea was irradiated with an irradiance of 10 mW/cm2 for 9 minutes. All patients were followed for 3 months. Pre- and postoperative measurements of corneal density, demarcation line and corneal stroma were assessed using Pentecam HR, anterior-segment OCT and HRT3 confocal microscopy.

Results:

The anterior 120 um layer corneal density increased postoperatively, reached summit at 15 to 30 days and then fell. The most significant increase were found in the 10 minutes iontophoresis group. Demarcation lines were detected in 90% (9/10) 10 minutes iontophoresis group, 70% (7/10) 5 minutes iontophoresis group, and 40% (4/10) hypo-osmolar riboflavin group; and the depth of demarcation line were 287 ± 45 um, 175 ± 51 um, 128 ± 48 um respectively (P< 0.05). Confocal microscopy revealed the activation of corneal stromal cells between 1 and 3 months, which was remarkable in 10 minutes iontophoresis group.

Conclusions:

In these three TE-CXL techniques, 10 minutes iontophoresis seemed to induce most significant corneal biomechanical changes, which was detected in standard epi-off CXL.

Financial Disclosure:

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