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September 2003
IN THIS ISSUE

New device creates alcohol-free epithelial flaps to improve healing and reduce haze


New IOL fixes suture-free in capsule-less eyes

Researchers race to produce bionic vision

Implantable telescope shows promise in AMD

New IOL Tackles Anterior-Capsule-Related Complications

Prospective study shows water jet phaco as effective as ultrasound for majority of cataracts

Laser microkeratome may reduce flap complications and improve visual outcome

Customised wavefront-guided ablation: exciting technology but beware the hype

Multifocal ablation results promising in presbyopia

In line phaco-filter aims to improve safety

Studies link genes to age-related cataract

Human genome project yielding clues to the aetiology of many ophthalmic disorders

New IOL 'adjusts' postoperatively to target refraction

Cold phaco heats up as new era dawns

Hartmann-Shack aberrometer finds new application in evaluation of nuclear cataract

Refractive surgery can improve quality of life - survey

Large retrospective study supports early intervention in paediatric cataracts

Study tracks blade influence on flap thickness

Study shows multifocal IOL implantation provides good binocular vision

Study revives hyperopic LASIK centration debate

Phakic IOL better than LASIK for high myopia

Getting to grips with ocular herpes

New rounded IOL edge design reduces glare

25-gauge vitrectomy needle speeds surgery

Indications for botulinum toxin treatment continue to expand

Experts debate value of customised ablation

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From The Editor
Reflections on Refractive Surgery
Prime Site
Bio-ophthalmology
Eye On Travel
Collectors Eye
Regulatory Matters


Study shows multifocal IOL implantation provides good binocular vision

Stefanie Petrou-Binder MD in Ludwigshafen

PATIENTS implanted with distance-dominant multifocal IOLs in one or both eyes experience good stereoacuity that does not benefit from additional near-vision correction, report German researchers.

Andreas Reuland MD and his colleagues conducted a clinical study that investigated near-oriented stereoacuity in 33 patients who received multifocal IOLs in one or both eyes. The surgeons performed uncomplicated cataract surgery in each patient and implanted 50 SA 40 N, AMO Array IOLs (Advanced Medical Optics). The AMO Array is a distant-dominant, multizonal, refractive silicone multifocal IOL.
Sixteen patients, mean age 55 years, received the multifocal IOL in one eye. Another seventeen patients, mean age 59 years, underwent bilateral implantation of the lens. Their ages averaged 59 ± 12 years. The study excluded patients with amblyopia or unusual orthoptic conditions.

The researchers tested stereoscopic vision at various times between three months and three years after multifocal implantation. They implemented the Lang Test ("cat" 1200 sec. arc, "star" 600 sec. arc, "car" 550 sec. arc) and the TNO random dot stereo-test (480-15 sec. arc), with and without near visual correction.
Dr Reuland explained that smaller sec. arc. values indicate better stereoacuity. The Lang test uses like images, slightly set apart, that eyes with stereoscopic vision should be able to superimpose, forming one image. Therefore the cat is the easiest to superimpose requiring 1200 sec. arc., while the car can be superimposed at 500 sec. arc.

The sixteen eyes with unilateral multifocal IOL implantation achieved uncorrected near visual acuity of 0.4 (± 0.2). Their best corrected near visual acuity was 0.6 (± 0.2). Twelve of the sixteen one-sided study participants recognised the car image (550 sec. arc) in the Lang test. Two additional patients recognised the car image with the aid of near visual correction.

The TNO Stereo-test results revealed that nine out of sixteen unilateral patients achieved stereoscopic visual acuity of 140 (± 80) sec. arc. Seven patients could not recognize anything. Two of these patients profited from near visual correction. With the help of near visual correction, ten of the sixteen patients in this group attained stereoacuity of 130 (± 70) sec. arc.

The investigators measured the uncorrected near visual acuity of the seventeen bilaterally implanted patients at 0.45 (± 0.2). Their corrected near visual acuity averaged at 0.7 (± 0.3).

The Lang Test revealed that fourteen patients in that group could recognise the car (550 sec. arc). One further patient recognised the car with near visual correction.
Ten of the seventeen patients achieved stereoscopic visual acuity results of 180 (± 140) sec. arc in the TNO Stereo-test. As in the unilateral group, seven of the binocular group patients recognised nothing. Another three profited from near visual correction. With near visual correction, eleven out of seventeen patients had stereoacuity of 160 ± 150 sec. arc.

Dr Reuland explained that older patients who receive monofocal IOLs have reduced stereoacuity. Binocular vision is one of the visual functions that researchers have often neglected to include in their functional study results after cataract surgery. He pointed out that few studies as yet can attest to the effects on stereoacuity following multifocal IOL implantation in one or both eyes.

He noted that the development of so-called 'comfort IOLs' such as aspherical and blue-filter IOLs (AcrySof Natural) have called an increasing amount of attention to high scoring visual acuity and functional tests that do not, however, necessarily include binocular visual acuity.

He emphasised that his study showed that some two-thirds of the patients in both the patient groups achieved good functional stereoscopic visual acuity without additional visual aids. Near visual correction did not provide a significant improvement in either group.

Dr Reuland suggested that stereoscopic visual tests be carried out on elderly patients receiving monofocal IOLs, as well.
Although H Burkhard Dick, MD has not been testing IOL recipients for stereoacuity at the Mainz University Eye Clinic, he does consider Dr Reuland's multifocal investigation promising.

"Patient age decreases the quality of stereopsis. Older patients, like those in Dr Reuland's investigation, are not expected to have good near stereoacuity. The study results highlight another interesting aspect of multifocal efficacy, which provides these patients with an improved quality of life."
Dr Dick contended however that it may be better to implant multifocal IOLs bilaterally, as studies have affirmed an advantage, primarily for improving anisometropia, as well as providing better stereoacuity outcomes.

He said that including stereoacuity in the roster of functional tests that ophthalmologists perform post-operatively might swamp clinicians. Stereoacuity investigations are more interesting from a scientific than every-day viewpoint.
Not all trials seem to concur with that of Dr Reuland in terms of a unilateral/bilateral advantage for improved stereoacuity results.

Anja Liekfeld MD investigated stereoscopic vision in eyes implanted with different lens types, both mono- and multifocal, in a trial involving 153 young and older phakic patients (Ophthalmologe 2002, Jan;99(1):20-4). Lenses were implanted uni- and bilaterally.
The outcome of her investigation revealed that all of the patients with both bilaterally implanted multifocal IOLs and bilaterally implanted monofocal IOLs had good binocular vision, for far and near. The patients with unilaterally implanted lenses scored lowest.

Andreas Reuland MD
Ruprecht-Karls-University Heidelberg Eye Clinic
Heidelberg, Germany
andreas.reuland@med.uni-heidelberg.de

H Burkhard Dick MD
Mainz University Eye Clinic, Mainz, Germany
bdick@mail.uni-mainz.de

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