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Effects of fluoxetine on the treatment of amblyopia

Poster Details

First Author: M.Talebnejad IRAN

Co Author(s):    M. Sharif   k. Rastegar                 

Abstract Details


Since it has been found that fluoxetine may increase neuronal plasticity. This research considered its effect on treatment of amblyopia. We assessed the effect of this medication on various aspects of visual functions including contrast sensitivity, streropsis as well as its impact on VEP latency 15 and 60 minutes.


Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


Following ethical approval, thirty –five amblyopic cases were recruited. They were divided into two groups of medication and placebo that were under treatment for 90 days. In both groups occlusion of healthy eye was done for 4-6 hours a day together with visual activities such as reading, watching TV and playing video games. Visual acuity (VA), contrast sensitivity, stereopsis and WEP were assessed before and after treatment.


VA, contrast sensitivity and stereopisis all revealed improvement in both groups after treatment. Higher latency for 60-minute period, improved to normal levels in both groups, while for the fluoxetine group (0.24logMAR) compare to placebo(0.12 logMAR).VEP latency for 60-minute improved to normal in both groups while for the fluoxetine group alone the improvement was observed for 15-minute period as well.


Fluoxetine is and effective treatment of amblyopia following the critical period significantly however further studies are required.

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