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Comparison of the long-term changes in the structure of colored acrylic intraocular lenses

Poster Details

First Author: K.Kawai JAPAN

Co Author(s):                        

Abstract Details

Purpose:

Six brands of colored acrylic intraocular lenses (C-A-IOLs) were selected. The weight of the lens, the diameter of the optic, and the thickness of the optic were examined in conjunction with lens deformation after a severe accelerated deterioration test.

Setting:

Department of Ophthalmology, Tokai University School of Medicine

Methods:

Six brands of colored acrylic intraocular lenses were used. Hydrophobic acrylic IOLs: SN60WF (Alcon), AN6K (Kowa), NS-60YG (Nidek), ZCB00V (AMO) and YA-60BBR (Hoya). Hydrophobic-hydrophilic hybrid acrylic IOL: NX-60 (Santen). Each IOL was placed in a 50 ml screw-tube bottle containing ultrapure water, and immersed for 115 days at a temperature of 100°C which is equivalent to 20 years. The state of the IOL prior to accelerated deterioration served as the baseline. The percent change in the weight of the lens, the diameter and the thickness of the optic was examined.

Results:

After accelerated deterioration, the percent change in the weight of the lens was -1.23% for SN60WF (-2.45% after drying) and -5.41% for AN6K (-11.89% after drying), indicating a significant decrease. The percent change in the diameter of the optic was -0.34% for SN60WF (-0.84% after drying) and -3.58% for AN6K (-5.03% after drying), indicating a significant decrease. The percent change in the thickness of the optic was +2.52% for SN60WF (+3.52% after drying), indicating a significant increase.

Conclusions:

The percent change in the weight of the lens and the diameter of the optic decreased significantly for SN60WF and AN6K. This is presumably because esters in cast-molded IOLs are readily hydrolyzed into their constituent acryl acid and alcohol during the severe accelerated deterioration test. Thus, IOL loses mass and deforms.

Financial Disclosure:

One or more of the authors receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented., One or more of the authors research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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