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Eyelid myeloid sarcoma as a presenting sign of acute myeloid leukemia

Poster Details

First Author: J.Nobre-Cardoso PORTUGAL

Co Author(s):    S. Barros   A. Miranda   N. Marques   S. Parreira   B. Beltran   N. Campos     

Abstract Details

Purpose:

To describe a clinical case of a patient with a previously unknown diagnosis of acute myeloid leukemia (AML), that was discovered due to the development of a chloroma in the inferior palpebral conjunctiva of the right eye (RE).

Setting:

Department of Ophthalmology, Hospital Garcia de Orta, E.P.E.

Methods:

Case report of a single patient.

Results:

A 91-year-old man presented to us with a two-week history of a mass in the inferior palpebral conjunctiva, progressively increasing in size, with no other ocular complains. He had a medical history of treated skin malignant melanoma and testicular cancer. His general examination revealed multiple subcutaneous nodules that had recently appeared. He was submitted to ocular surgery for excision of the mass. The pathological report revealed a diagnosis of myeloid sarcoma (positive for CD45, TdT and CD4) secondary to AML. He was admitted for treatment, but due to the advanced stage of the disease, the treatment failed and the patient died.

Conclusions:

We present a very rare case in which a previously unknown diagnosis of acute myeloid leukemia was done due to the appearance of a chloroma in the lower eyelid. Choromas (or myeloid sarcomas) are a rare form of solid tumors that are associated with AML and other myeloproliferative disorders. They can appear in any organ or tissue but are more common in the skin. Very rarely, they can affect the eye or the periorbital tissues. Their urgent excision is important for the rapid diagnosis of the underlying disorder, since it is usually treatable in the early stages.

Financial Disclosure:

NONE

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