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The role of structural changes in early detection of glaucoma in pseudoexfoliation syndrome

Poster Details

First Author: K.Novak-Lauš CROATIA

Co Author(s):    M. Simic-Prskalo   Z. Tomic                 

Abstract Details


Aims of this study are to correlate structural and functional changes in group of examinees with unilateral pseudoexfoliation syndrome and to examine the value of these parameters in early detection of glaucoma in group of examinees.


Department of Ophthalmology, Clinical Hospital Center ''Sestre milosrdnice'' Zagreb, Croatia


Prospective research has conducted in Clinical Hospital Center "Sestre milosrdnice" and it involved 30 examinees with unilaterally PEX syndrome. After detailed clinical examination, automated static perimetry has been done on an Octopus perimeter using G2 program for measuring indices of diffuse and local defect and optical coherence tomography for measuring and noting average thickness of retinal nerve fiber layer and also theirs thickness in all four quadrants (ISNT rule). Control group consisted of examinees in age above 50 years without presence of glaucoma or PEX syndrome. Results were presentes with parameters of descriptive statistics.


In group with uniliterally PEX syndrome, along with increasement of value MD statistically increases sLV value. In eye with manifest PEX syndrome as well as fellow eye was recorded minimal value of average RNFL, inferior and superior quadrant, below referent values. However that structural changes haven't manifested with defects in VF and speak for presence of preperimetric glaucoma. Arithmetic mean of all examined parameters was within referent values. There were more fellow eyes with referent values of inferior quadrant thickness (86.67%), superior quadrant (96.67%) than eyes with manifest PEX syndrome in inferior quadrant (83.33%) and superior quadrant (90%). Majority of examinees with average RNFL thickness within referent values were equal as in manifest and fellow eye (73.33%).


Average thining of retinal nerve fiber layer, especially in inferior, and than superior quadrant have not resulted in visual field defects in group of unilateral PEX sindrome. However that structural changes have an important role in early detection of glaucoma for risk group of examinees.

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