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Relationship between visual field changes and optical coherence tomography measurements in advanced open-angle glaucoma

Poster Details

First Author: S.Kostianeva BULGARIA

Co Author(s):    M. Konareva-Kostianeva   M. Atanassov                 

Abstract Details

Purpose:

To evaluate the relationship between functional changes in visual field and structural changes established by spectral-domain optical coherence tomography (SD-OCT) in advanced open-angle glaucoma (OAG).

Setting:

Department of Ophthalmology, Medical University Plovdiv, Bulgaria

Methods:

Thirty one eyes of 25 patients with OAG (mean age 63.1±10.9 years) are included in this study. Except routine ophthalmological exam the patients undergo standard automated perimetry – SAP (Humphrey Field Analyzer) and SD-OCT (RTV-ue – 100), done within 6 months. The global perimetric indices in the study group are as follows: Mean Deviation (MD) – 12.33±6.18dB and Pattern Standard Deviation (PSD) 9.17±3.41dB. The relationship between OCT measurements and the global indices MD and PSD is established by correlation (Pearson’ correlation coefficient) and regression (linear and nonlinear regression models) analyses.

Results:

The measurements of the lower halves of ganglion cell complex (GCC), retinal nerve fiber layer by scanning protocol ONH – RNFL 1 and retinal nerve fiber layer by scanning protocol 3.45mm – RNFL 2 (76.75±17.84 µm; 77.63±17.64 µm, 72.29±15.55 µm) present smaller thickness in comparison with those of the upper halves of GCC, RNFL 1 and RNFL 2 (80.20±21.95µm, 78.34±17.64µm, 73.87±14.60µm respectively), however without statistically significant difference. On the base of regressive analysis it is found that GCC correlates better with RNFL 1 (R² = 0.572, P<0,001) than with RNFL 2 (R² = 0.301, P=0,011). Correlation between global indices MD/PSD and most examined quantitative OCT measurements are moderate (with R between 0.3 and 0.6).

Conclusions:

The association between MD and GCC-Ave shows nonlinear cubic regression (R2 = 0.417, P=0.004). Good relationship is found between MD and GLV (R2 = 0.383; P=0.008). Linear regression (with P<0.05) is estimated only between MD and Cup Area (R2 = 0.175, P=0.024) and between MD and RNFL 2 (R2 = 0.131, P=0.045). Nonlinear regressive models appear to be more appropriate in evaluation of relationship between functional and structural changes in eyes with advanced glaucoma. The moderate correlation is established in this study.

Financial Disclosure:

NONE

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