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Comparative evaluation of cytotoxicity of antimicrobial eye drops

Poster Details

First Author: I.Okolov RUSSIA

Co Author(s):    Y. Takhtaev   T. Hintuba   O. Aleksandrova   J. Khorolskaya   M. Blinova        

Abstract Details

Purpose:

To compare in vitro the overall cytotoxic effects of six antibacterial fluoroquinolone eye drops

Setting:

1 Institute of Cytology of the Russian Academy of Science, Saint-Petersburg 2 S. Fyodorov IR&TC “Eye Microsurgery”, St.-Petersburg, Russian Federation 3 State budget institution of higher education “North-Western State Medical University named after I.I. Mechnikov” under the Ministry of Public Health of the Russian Federation, Saint-Petersburg

Methods:

The overall cytotoxic effects of Cipromed™ (ciprofloxacin 0,3%; Sentiss Pharma Pvt. Ltd., India); Floxal™ (ofloxacin 0,3%; Dr. Gerhard Mann, Chem.-Pharm. Fabrik GmbH, Germany); Oftaquix™ (levofloxacin 0,5%; Santen Oy, Finland); Signicef® (levofloxacin 0,5%; Sentiss Pharma Pvt. Ltd., India); Vigamox® (moxifloxacin 0,5%; Alcon Laboratories, Inc., USA); and Zymar® (gatifloxacin 0,3%; Allergan Sales LLC, USA) were compared in vitro. Two types of cells were used in the experiment: cells transformed with a constant cell line (ovary cells Chinese hamster tumor) and normal human skin fibroblasts. The concentration of the test drugs was equal to 1.25% of the volume of culture medium

Results:

The cytotoxic effects of antibacterial fluoroquinolone on the cells transformed with a constant cell line were found in the following order (descending toxicity): moxifloxacin greater-than levofloxacin (original) greater-than levofloxacin (generic) greater-than gatifloxacin greater-than ciprofloxacin greater-than ofloxacin. The cytotoxic effects of antibacterial fluoroquinolone on the human skin fibroblasts were found in the following order (in descending toxicity): ciprofloxacin ≥ moxifloxacin, gatifloxacin greater-than levofloxacin (generic) = levofloxacin (original) greater-than ofloxacin

Conclusions:

The study showed a possibility of using cultured cells for comparative evaluation of the cytotoxic effects of various ophthalmic preparations. We found that antimicrobial medicines that had been tested in vitro differ in their cytotoxic potential

Financial Disclosure:

NONE

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