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Effectiveness of corneal collagen cross-linking with hypoosmolar riboflavin solution in keratoconic corneas

Poster Details

First Author: B.Kambo ALBANIA

Co Author(s):    K. Bardhi   M. Asani                 

Abstract Details


To report the 12-month outcomes of corneal collagen cross-linking (CXL) with a hypoosmolar riboflavin and ultraviolet-A (UVA) irradiation in thin corneas.


German Eye Clinic, Tirana Albania


Eight eyes underwent CXL using a hypoosmolar riboflavin solution after epithelial removal. The best corrected visual acuity (BCVA), manifest refraction, the mean thinnest corneal thickness (MTCT), and the endothelial cell density (ECD) were evaluated before and 6 and 12 months after CXL


The MTCT was 421.4 ± 12.4?µm before treatment and reduced to 381.1 ± 8.4?µm after the removal of the epithelium. After CXL, the thickness decreased to 414.3±?14.5µm at the last follow-up. Before treatment, the mean K-value of the apex of the keratoconus corneas was 56.7 ± 3.2 diopters and slightly decreased (55.6 ± 4.4 diopters) at 12 months. The mean BCVA was 0.44 ± 0.22 of resolution before treatment and increased to 0.48 ± 0.24 at the last follow-up. The ECD was 2731.4 ± 184.5 cells/mm2 before treatment and was 2732.4 ± 212.6 cells/mm2 at 12 months after treatment


CXL with a hypoosmolar riboflavin in thin corneas is effective method for keratoconic eyes with the mean thinnest corneal thickness less than 400 µm without epithelium.

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