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Experimental basing of new device for optimized UV-crosslinking: technique, efficacy and safety

Poster Details

First Author: S.Izmailova RUSSIA

Co Author(s):    B. Malyugin   D. Merzlov                 

Abstract Details


To evaluate efficacy of a new disrupter model epithelium-off UV-crosslinking in the experiment.


The S. Fyodorov Eye Microsurgery Federal State Institution, Russia.


There was developed a new disrupter model for optimized UV-crosslinking technique that allows performing a topo-guided dosed corneal epithelium scarification with graduated vacuum ring, supporting plate of working piece which is congruent to corneal surface, and spring-mechanism that allows the pins to move out for the necessary depth. The efficacy of the method was first evaluated with infrared Fourier-spectroscopy and specific reflection spectrums evaluation. The efficacy criterion was proved corneal riboflavin penetration. The safety of the method was evaluated in vivo in chinchilla rabbit breed according to re-epithelisation time, which was revealed with OCT and confocal microscopy methods.


The IR-spectroscopy method with specific reflection spectrums evaluation in the model of optimized UV-crosslinking technique revealed full-thickness corneal penetration of riboflavin. In vivo experiments showed accelerated re-epithelisation, absence of specific complications. OCT and confocal microscopy did not reveal any damage of the anterior stroma layers due to new disrupter model use.


The experimental investigations of the optimized new device UV-crosslinking technique with dosed topo-guided epithelium scarification proved its efficacy and safety.

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