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Current protocols of corneal collagen cross-linking: visual, refractive and topographic outcomes

Poster Details

First Author: D.Haria INDIA

Co Author(s):    H. Nagaraj   N. Pahuja   R. Shetty              

Abstract Details


To study the effect of different protocols of collagen crosslinking on visual,refractive and topographic parameters in patients with progressive keratoconus.


Narayana Nethralaya Superspeciality Eye Hospital and Postgraduate institute of Opthalmology,Bengalore,India


In this prospective, interventional study, 172 eyes of 172 patients with progressive keratoconus underwent corneal collagen crosslinking (CXL). Following detailed preoperative examination, Group I underwent conventional crosslinking (36 patients, 3mW/cm2) while groups II (36 patients, 9mW/cm2), group III (33 patients, 18mW /cm2), Group IV (33 patients, 30mW/cm2) and Group V (34 patients, 45mW/cm2) underwent accelerated crosslinking. Epithelium was debrided in groups I - IV while patients in group V underwent a transepithelial CXL. Changes in CDVA, SE, flat K, steep K, thinnest pachymetry, specular microscopy and demarcation line were studied.


Improvement in mean CDVA and SE were statistically significant in all groups except group IV (p=0.15, p=0.17) with group III (p=0.02) showing the best results. Flattening of steep and flat keratometry was significant in group I (p<0.001) and II (p=0.002) as compared to the other groups. There was no significant difference in the pachymetry or specular microscopy change in any of the groups. Group I and II demonstrated a good demarcation line when compared to other groups.


Conventional CXL (group I) and accelerated CXL with irradiations of 9mW/cm2 (group II) and 18mW/cm2 (group III) showed better visual, refractive and topographic improvements at the end of 12 months.

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