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Trans-epithelium accelerated corneal collagen cross-linking in treating primary keratoconus with different UVA fluencies

Poster Details

First Author: S.Chen CHINA

Co Author(s):    Y. Li   J. Zhang   P. Ding   Q. Wang           

Abstract Details

Purpose:

To evaluate the effectiveness and safety of trans-epithelium accelerated corneal collagen cross-linking (CXL) in treating primary keratoconus with different ultraviolet intensity and irradiation time.

Setting:

Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Methods:

A total 27 primary keratoconus eyes of 27 patients were enrolled. After riboflavin solution application, 15 eyes received 45 mW/cm2 UVA irradiation for 2 minutes and 40 seconds, the other 12 eyes received 20 mW/cm2 UVA irradiation for 6 minutes. Both groups received a total UVA energy of 7.2 J/cm2.The follow-up period was 12 months.

Results:

12 months after treatment, there was an improvement of 0.35±0.07 logMAR in best-corrected visual acuity in 45 mW/cm2-group and 0.09±0.03 logMAR in 45 mW/cm2-group. The spherical diopter decreased 1.38±0.41 D and the cylindrical diopter decreased 0.37±0.21 D in 45 mW/cm2-group, while that was 1.00±0.29 D and 1.40±0.45 D in 20 mW/cm2-group, respectively. A progressive decrease of 1.41±0.46 D in Kmax in 45 mW/cm2-group and 2.01±0.62 D in 20 mW/cm2-group was noted. The decrease in AE and PE, surface regularity index, surface asymmetry index in both groups were statistically significant. Contrast sensitivity improved in both scotopic and lower glare conditions (all ps < 0.05).

Conclusions:

Trans-epithelium accelerated CXL with 45 mW/cm2 and 20 mW/cm2 UVA intensity both showed to be effective and safe in treating primary keratoconus. After 12-month follow-up, 20 mW/cm2 UVA intensity showed better results. But for those poorly cooperated patients, 45 mW/cm2 would be a better choice for its shorter irradiation time.

Financial Disclosure:

NONE

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