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Five year results of thick graft endothelial keratoplasty in a patient with brittle cornea syndrome: a new approach for keratoglobus

Poster Details

First Author: J.Hasanov AZERBAIJAN

Co Author(s):                        

Abstract Details


To evaluate the efficacy of first use thick graft - endothelial keratoplasty in a patient with advance keratoglobus.


Zarifa Aliyeva National Eye Center


We reported of a 5-year-old girl with brittle corneal syndrome presented to Zarifa Aliyeva National Eye Center in April 2010. Hydrops (right eye) secondary traumatic Descemet’s membrane detachment underwent Descemet stripping endothelial keratoplasty. The large (9.5 mm in diameter) and thick (400 ± 27 μm) donor endothelial lenticule was used for the procedure. Visual acuity, refraction, keratometry, intraocular pressure, fundus examination, recipient and graft corneal thickness was measured before surgery and during 60 months follow up. For monitoring and quantification of the dynamics of the recipient and recipient/donor corneal response was used anterior segment ocular coherent tomography.


The best-corrected visual acuity on right eye light perception and left eye 0.1. Intraocular pressure in both eyes was within normal limits before and after surgery. The mean central corneal thickness was 327 μm on right eye (edema 4+) and 260 μm on left eye preoperatively. The cornea was completely transparent on the third week after surgery. Mean central recipient:donor:recipient/donor corneal thickness (from 3 to 60 months period) was 175.3±5.9: 260.3±9.7: 437.9±14.2 respectively. Visual acuity was stable (Vis = 0.1), corneal clear, and no episode of graft rejection was observed.


To the best of our knowledge, this case is the first documented. Thick Graft - Endothelial Keratoplasty may be acceptable technique for providing tectonic tissue support, visual recovery, stabilizing eyes with advance keratoglobus, reducing myopia power and graft failure rate.

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