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Autoconjunctivoplasty and limbus allotransplantation in recurrent repeatedly-operated pterygiums

Poster Details

First Author: T.Diana RUSSIA

Co Author(s):    K. Alexander   R. Michail   L. Evgeniya   S. Sergey   G. Otello   G. Oleg     

Abstract Details

Purpose:

Analysis of autoconjunctivoplasty and limbus allotransplantation in recurrent repeatedly operated pterygiums.

Setting:

FSBI “The Academician S.N. Fyodorov IRTC “Eye Microsurgery” of the Ministry of Public Health of the Russian Federation, Krasnodar Branch

Methods:

From 48 eyes, 28 (58.5%) were operated doubly, 8 (16.5%) - three times, 12 eyes (25%) – more than three times. Autoconjunctivoplasty was performed in 42 eyes by standard method, when the transplantant size was determined by the defect area. In 6 cases - limbus allotransplantation. Limbus allotransplantants conservation was performed in the modified environment DMEM/F12 with glutamine in terms of CO2-incubator for 30 days. On the limb area within the dissected body of the pterygium was fitted stripe of sclerolimbal transplant up to 10 x 2 mm, fixation by interrupted sutures. The defect area was covered with free autoconjunctival flap.

Results:

In 6 cases of allolimbal transplantation in early postoperative period there was the complete epithelialization of corneal defect on average within 3 days. Conservation of limbus allotranslantants allows significantly increase the number and activity MSC-like limbus cells and to eliminate the histocompatibility antigens from the transplantat. Patients didn’t get immunosupresivny therapy. In 42 cases of completed autoconjunctivoplasty the problem of partial limbus deficiency didn’t resolve that led to relapses in 6 (14,2%) cases over the three year period of observation.

Conclusions:

Transplantation of allogenic limbus, conserved by normothermia within 30 days, in recurrent pterygiums is perspective, pathogenetically reasonable treatment method, which doesn’t require immunosuppressive therapy and allows to achieve long-term remission, eliminating sectoral limbus deficiency. Autoconjunctivoplasty in recurrent repeatedly operated pterygium is recommended time-proved method, which allows to achieve optimal anatomical, cosmetic and functional result; significantly reduces relapses to 14.2%.

Financial Disclosure:

NONE

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