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The causes of development of recurrent forms of adenoviral keratoconjunctivitis and approaches to treat them

Poster Details

First Author: T.Valkovich BELARUS

Co Author(s):                        

Abstract Details

Purpose:

Determine the causes of recurrence of adenoviral keratoconjunctivitis.

Setting:

Belarusian Medical Academy of Post-Graduate Education, Russia

Methods:

The study was performed in 13 patients with a diagnosis recurrent adenoviral keratoconjunctivitis. All patients underwent ophthalmologic examination including medical history, external examination, biomicroscopy. ELISA and PCR on adenoviral infection, cytomegalovirus infection (CMV) and herpes simplex virus (HSV) I and II types was performed on all patients.

Results:

Disease duration ranged from 3 months to 2 years, the recurrence rate - 2 times a year to chronic course. All patients had herpetic eruptions more than 3 times a year. Previous treatment included steroidal anti-inflammatory drugs or combined with an antibiotic. Several patients reported self-administration of these drugs for recurrent disease. ELISA results revealed exceeded titers of antibody to CMV IgG 12.2 times, in patients with a continuous flow or frequent relapses - in the 111.2 - 1544.6 times, to HSV - 5 times. PCR of lacrimal fluid was negative in all cases. Carrying out local (Virgan) and systemic (Valacyclovir) etiotropic therapy prevented recurrences in 84.6% of cases.

Conclusions:

Adenoviral keratoconjunctivitis recurrent require additional examination of the patient to determine the mixed infection. One of the causes of recurrent forms of adenoviral keratoconjunctivitis is the development of mixed infections associated with the herpes virus types 1 and 2 and cytomegalovirus. Upon confirmation of herpes virus etiology of the disease is necessary to conduct local and systemic (if necessary) etiotropic therapy. Conducting etiotropic therapy allowed preventing recurrence of the pathological process in 84.6% of cases.

Financial Disclosure:

NONE

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