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The effects of obstructive sleep apnea syndrome on the ocular surface

Poster Details

First Author: S.Aslan Bayhan TURKEY

Co Author(s):    K. Kirboga   H. Bayhan   Y. Intepe   E. Muhafiz   C. Gurdal        

Abstract Details


To assess the ocular surface changes, patient comfort and tear osmolarity in patients with obstructive sleep apnea syndrome (OSAS).


Bozok University Faculty of Medicine, Ophthalmology Department, Yozgat, Turkey.


In this prospective study 54 eyes of 54 patients with OSAS and 36 eyes of 36 age- and body mass index-matched healthy subjects were enrolled. Full ophthalmologic examination, Schirmer test (with topical anesthesia), fluorescein break-up time (BUT), corneal fluorescein staining and tear osmolarity measurements with the TearLab system (TearLab Corporation) were performed. Participants also completed the ocular surface disease index (OSDI) questionnaire for evaluation of symptoms.


The mean age of the patients was 50.88±9.54 and 48.51±9.78 years in OSAS and healthy subjects respectively. 18 eyes (% 33.3) had floppy eyelid syndrome in OSAS group and 2 eyes (%5.5) in control group (p<0.001). Mean tear osmolarity measurement of the OSAS group (314.72±6.12 mOsm/L) was significantly higher than that of the control group (284.44±9.27 mOsm/L, p<0.001). Fluorescein BUT measurements were 7.42±3.14 seconds and 11.10±3.72 seconds (p<0.05); and Schirmer results were 12.44±1.78 and 14.30±2.71 mm/5 min (p>0.05) in the OSAS and control groups, respectively. OSDI score of the control group was lower than the OSAS group (11.85±10.63 vs, 39.1±20.15 p<0.001) and punctate epitheliopathy was seen in 50% of OSAS eyes


The findings of this study indicate that OSAS causes significant signs and symptoms of dry eye. Thus, regular screening of OSAS patients for dry eye is helpful for ocular surface health of this particular population

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