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Effect of diquafosol 3% ophthalmic solution on ocular surface and corneal aberration after cataract surgery

Poster Details

First Author: K.Sangmyung SOUTH KOREA

Co Author(s):    S. Park   Y. Ji   H. Lee   K. Seo   E. Kim   T. Kim     

Abstract Details


To evaluate the effect of diquafosol 3% ophthalmic solution on tear film parameters and ocular aberration after cataract surgery in eyes with mild and moderate dry eye syndrome.


The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea


Patients who underwent cataract surgery were divided into two groups. Patients in group I (19 eyes) were treated with diquafosol 3% ophthalmic solution from 1 week before surgery to 3 months after surgery. Patients in group II (22 eyes) underwent cataract surgery without application of diquafosol 3% ophthalmic solution. Tear film break-up time (BUT), Ocular surface disease index (OSDI), Oxford staining score, Schirmer’s test I, and corneal aberrations were evaluated before and 1, 3 months after cataract surgery.


In group I, BUT, OSDI, and Oxford staining score were significantly improved at 1 month (P=0.002, 0.005, 0.005) and 3 months (P=0.004, 0.005, 0.020) after surgery compared with preoperative value. However, tear production decreased significantly at 3 months after surgery (P=0.011). Regarding the BUT, OSDI, and Oxford staining score, group 1 showed the tendency to demonstrate better results after cataract surgery. Especially. OSDI in group I was significantly lower than that in group II at 1 month and 3 months after surgery (P=0.013 and P=0.035). In group 1, root mean square higher-order aberration, Trefoil 6, and Trefoil 10 decreased at 3 months after surgery. Other parameters for ocular aberration showed comparable results between the two groups.


Use of Diquafosol 3% ophthalmic solution before and after cataract surgery can be effective for improving dry eye syndrome and corneal aberration after cataract surgery.

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