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Cyclosporine A 0.05% emulsion after cataract surgery for ocular surface problems and corneal sensation

Poster Details

First Author: S.Hamada UK

Co Author(s):    T. Moore   J. Moore   M. Dreihi   A. Anbari   S. Shah        

Abstract Details

Purpose:

The aim of this study was to assess the safety and efficacy of topical cyclosporine-A (CsA) 0.05% ophthalmic emulsion used after cataract surgery to improve the ocular surface and hence surgical outcomes, and also to explore the possibility of CsA accelerating the recovery of corneal sensation.

Setting:

The Corneo Plastic Unit and Eye Bank, Queen Victoria Hospital in East Grinstead in the UK which is a national referral centre for corneal disease.

Methods:

Prospective, randomized, double masked clinical trial of adult patients attending for bilateral cataract surgery.Patient’s eyes were randomised into two groups.The first group received topical CsA0.05% ophthalmic emulsion Restasis® 2-daily for 1month following surgery. The second group used carboxymethylcellulose 0.5%CMC preservative-free Refresh-Plus® drops on the same regimen following surgery.Subjective and objective assessments were performed pre-operatively,one week,one month after surgery. Primary safety parameters included best spectacle-corrected visual acuity and incidence of adverse events.Objective assessments included tests of tear film (osmolarity, tear break up time, and Schirmer’s type-I test), ocular surface staining, corneal sensitivity.Subjective assessment: ocular surface disease index (OSDI) questionnaire.

Results:

30 subjects (60 eyes) were recruited. At one month following cataract surgery, osmolarity, ocular surface staining, TBUT, Schirmer’s results showed more improvement after CsA drops compared to CMC and this was statistically significant for all measures (p<0.05). All corneal sensation measurements were reduced after one week and one month. Eyes receiving CsA had higher recovery of corneal sensation at both time points post operatively and this was statistically significant at one month. OSDI questionnaire results did not show a statistically significant difference between the two eyes.

Conclusions:

CsA is effective and safe in the management of ocular surface problems after cataract surgery and allows faster recovery of corneal sensation.

Financial Disclosure:

NONE

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