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Preliminary report on adverse events of early intensive topical steroid therapy in presumed bacterial keratitis

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Session Details

Session Title: Presented Poster Session: News on Phaco

Session Date/Time: Tuesday 08/09/2015 | 09:30-11:00

Paper Time: 10:50

Venue: Poster Village: Pod 4

First Author: : G.Fenech UK

Co Author(s): :    P. Chiam   S. Ch'ng   V. Savant   J. Prydal     

Abstract Details


To analyse the outcome and adverse effects of early intensive topical steroid use in the treatment of presumed bacterial keratitis.


Ophthalmic Department, Leicester Royal Infirmary, UK.


Retrospective review of clinical notes for outcome and adverse events in consecutive patients who had corneal scrape performed for presumed bacterial keratitis and at least 2 hourly g.dexamethasone 0.1% preservative-free started within 3 days of presentation. Steroids were only used in cases where there was evidence of a bacterial infection, and were not used in the presence of atypical signs. The study period was from May 2009 to February 2013. The best-corrected visual acuity (BCVA), intraocular pressure (IOP), culture results and adverse effects were recorded.


There were 39 eyes. Median age was 41-years. The median time to intensive steroid commencement was 2 days from presentation and median duration 10 days. The BCVA at presentation, day 3±1, 6±1, 14±1, month 1 and 2 were logMAR 0.78, 0.48, 0.30, 0.19, 0.18 and 0.18. The IOP on day 14±1, month 1 and 2 were 15, 16 and 15mmHg. No eyes had IOP greater than 25mmHg. The cultured bacteria were coagulase negative staphylococcus (38.5%), pseudomonas aeruginosa (28.2%) and streptococcus pneunomiae (7.7%). There was no perforation, delayed epithelial healing, infection recurrence or other adverse events documented within the first 2 months of follow-up.


This preliminary report shows intensive topical steroid commenced within 3 days in presumed bacterial keratitis treatment did not cause any adverse events.

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