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Tetracaine assisted debridement in PRK with intraoperative mitomycin C

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Session Details

Session Title: Photoablation Outcomes II

Session Date/Time: Wednesday 09/09/2015 | 08:00-09:30

Paper Time: 08:06

Venue: Room 1

First Author: : N.Nassiri IRAN

Co Author(s): :    K. Sheibani   S. Safi   N. Nassiri              

Abstract Details


To compare corneal stromal and endothelial cells after photorefractive keratectomy with intraoperative mitomycin C in tetracaine assisted versus mechanical epithelial debridement using confocal microscopy.


Imam Hossein Medical Center, Shahid Beheshti University Medical Sciences, Tehran, Iran.


This prospective randomized comparative study was performed on 88 eyes (44 patients) with myopia up to -6.00 diopters. The right eye of each patient was randomly assigned to either mechanical or tetracaine assisted groups, and the left eye was assigned to the alternate group. Confocal microscopy was performed preoperatively and at 3 months postoperatively. The main outcome measures were epithelial thickness; number of keratocytes in the anterior, mid, and posterior stroma; as well as characteristics of the central corneal endothelial cells including density, mean cell area, and polymegathism and hexagonality.


Three months after surgery, no statistically significant difference was noted between the study groups in terms of epithelial thickness. We also found no statistically significant difference in central corneal endothelial cells regarding cell density, mean cell area, hexagonality, or polymegathism. Compared with baseline values, the density of mid and posterior stromal keratocytes showed no significant change in either group, whereas it decreased significantly in the anterior stroma in both groups 3 months after surgery (p<0.001).


We found that the adverse effects of photorefractive keratectomy with mitomycin C on central corneal endothelial cells were comparable between the mechanical and tetracaine assisted epithelial debridement groups and the significant decrease in postoperative keratocyte density in anterior stroma was comparable between the two groups.

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