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NSAIDS vs steroids vs combination therapy in the prophylaxis of postoperative cystoids macular oedema

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Session Details

Session Title: PCO. Cataract Surgery Complications/Management

Session Date/Time: Tuesday 08/09/2015 | 08:00-10:30

Paper Time: 09:48

Venue: Room 1

First Author: : Y.Abubakr EGYPT

Co Author(s): :    A. Salah   E. Aboubakr El Siddek Ahmed                 

Abstract Details


To evaluate the safety and efficacy of using topical keratolac 0.4% drops vs topical prednisolone vs a combination therapy of both drugs in the prevention and management of acute pseudophakic cystoid macular oedema (CME).


Ophthalmology Department, Egypt Air Hospital, Cairo,Egypt.


Randomized prospective non masked open label trial including 120 patients randomly distributed into 3 groups, the first group received topical keratolac 0.4% ,the second received prednisolone acetate 1% suspension drops, the third group received a combination therapy of both drugs. Treatments were continued for 4 weeks postoperatively. Patients' assessment included Snellen visual acuity, IOP, OCT scanning of the macula at day 1 and 4,8,12 weeks.


Results showed that 57.5% of the Prdnisolone 1% montherapy group developed CME and increase in CMT at 1 month duration(P=.035) compared to 17,5% of the keratolac 0.4% group and 2.5% of the combined therapy group.(P=.001).


Combined topical NSAID and steroids showed superior efficacy in the prophylaxis and management of pseudophakic macular oedema compared to either drug monotherapy.

Financial Interest:


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