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Clinically relevant raw material properties of 4 intraocular lenses

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Session Details

Session Title: PCO. Cataract Surgery Complications/Management

Session Date/Time: Tuesday 08/09/2015 | 08:00-10:30

Paper Time: 08:00

Venue: Room 1

First Author: : C.Pagnoulle BELGIUM

Co Author(s): :                        

Abstract Details

Purpose:

To investigate comparatively the surface and bulk properties of the raw materials of four acrylic intraocular lenses (IOLs) – Micro AY, PodEYE, Acrysof and Acri.LISA.

Setting:

University of Liège, Belgium; University of Louvain-la-Neuve, Belgium; Research and Development Department, Physiol, Belgium; Centre Ophtalmologique IRIDIS, Albi, France; Clinique Beausoleil, Montpellier, France

Methods:

PodEYE (Physiol SA) is manufactured with the proprietary glistening-free hydrophobic material from Physiol SA. Acrysof (Alcon Laboratories Inc) is a hydrophobic aromatic material. Micro AY (Physiol SA) and Acri.LISA (Carl Zeiss Meditec AG) are hydrophilic IOLs with 25%-water-uptake, Acri.LISA having a hydrophobic surface. Clinical outcomes are available for CT Asphina as Acri.LISA-like predicate. The surface wettability, composition, refractive index and foldability were tested by contact angle, XPS, refractometry and creep recovery, respectively. The surface bioadhesion was evaluated in vitro with porcine lens epithelial cells (LEC). Clinically, the PCO rate was determined through the Nd-YAG laser rates 3-years postoperatively.

Results:

The wettability and surface composition of all lenses are comparable and typical for acrylics materials. The refractive index is 1.52-PodEYE, 1.55- Acrysof and 1.46-Micro AY and Acri.LISA. The hydrophilic lenses are more elastic and fold/unfold rapidly. The hydrophobic demonstrate visco-elastic properties thus fold/unfold longer, PodEYE recovering its initial shape faster. Higher rates of cell adhesion (51-75%) are determined in vitro for the hydrophobic IOLs, while both hydrophilic lenses showed extremely low surface coverage by the cells (< 0.5%), independently of the surface (with or without hydrophobic coating). Clinically, Nd-YAG treatments 3 years post-operatively were performed as follows: 0% for the PodEYE group, 4% for the Acrysof group, 32.4% for the Micro AY group and 32.5% for the CT Asphina group.

Conclusions:

The composition of the bulk material of an intraocular lens seems to have a stronger impact on its optical, mechanical and biological in vitro and clinical performance. For a same raw material, the surface treatment (e.g. hydrophobic surface on hydrophilic raw material) is likely to have negligible influence on the biadhesiveness and PCO resistance of the final implant. Hence, in the aqueous environment of the eye, groups from the bulk of the lens migrate to the surface and are at the origin of the implant biological performance clinically.

Financial Interest:

One of the authors is employed by a for-profit company with an interest in the subject of the presentation

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