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Comparative outcomes of tear osmolarity and other dry eye tests after LASIK vs photorefractive keratectomy (PRK)

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Session Details

Session Title: Photoablation Outcomes I

Session Date/Time: Monday 07/09/2015 | 16:30-18:30

Paper Time: 17:57

Venue: Room 17

First Author: : V.Charoenrook SPAIN

Co Author(s): :    P. Sauvageot   J. Alvarez de Toledo                 

Abstract Details


To compare the impact of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) on tear osmolarity and other dry eye tests.


Centro de OftalmologĂ­a Barraquer, Barcelona, Spain


A prospective and comparative study was done where 56 eyes of 56 myopic patients who underwent LASIK or PRK surgery and fulfilled the inclusion criteria were included in 2 matched groups. Dry eye tests were evaluated before the surgery and at 3, 6, and 12 months postoperatively, and included tear osmolarity, ocular surface disease index (OSDI) questionnaire, Schirmer I test with and without anesthesia, corneal esthesiometry, tear break up time (TBUT) and corneal staining.


No significant difference in dry eye tests between the 2 groups was observed at any point. Only corneal sensibility was significantly decreased in LASIK group compared to PRK group after 3 months (U=270; P=0,043). Corneal sensibility was significantly reduced after 3 months compared to preoperative values in both groups but recovered to statistically similar to preoperative values after 6 (PRK group) and 12 months (LASIK group). Tear osmolarity values were comparable to preoperative values after 3 months but significantly increased in both groups after 6 (LASIK group, P=0,04; PRK group, P=0,006) and 12 months (LASIK group, P=0,005; PRK group, P=0,004).


There was no significant difference in tear osmolarity and other dry eye tests between LASIK and PRK at any point of the follow-up except for corneal sensitivity which was significantly lower in the LASIK group than in the PRK group at 3 months postoperatively. Tear osmolarity significantly increased in both groups at 6 months after surgery compared to preoperative values, and remained statistically higher one year postoperatively. A longer follow-up will be necessary to assess whether tear osmolarity recovers its preoperative values after corneal refractive surgery.

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