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Effect of recipient age and surgical procedure on pediatric keratoplasty outcomes

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Session Details

Session Title: Cornea - Surgical III

Session Date/Time: Sunday 06/09/2015 | 14:15-16:15

Paper Time: 16:03

Venue: Room 16

First Author: : L.Buzzonetti ITALY

Co Author(s): :    R. Ardia   S. Petroni   G. Petrocelli   P. Valente   G. Iarossi        

Abstract Details


to evaluate the effect of surgery type (penetrating keratoplasty :PK or deep anterior lamellar keratoplasty - DALK) and recipient age on graft in pediatric corneal keratoplasty.


Ophthalmology Department, Bambino Gesù IRCCS Children's Hospital, Rome, Italy


Fifty-four eyes that underwent corneal keratoplasty from the 1st of January 2010 through the 31st of December 2013 were evaluated. In order to explore the effect of surgery type (PK or DALK) on the graft failure rate, a 2X2 table was developed and the Chi square test was used for testing the statistical significance. A similar table was used to compare the graft failure with the recipient age, after grouping patients with ≤5 and >5 years. The influence of age as potential risk factor for graft failure was also explored with a logistic regression analysis. P<0.05 was considered as significant.


Mean recipient age was 8,95,7 SD years. Mean follow-up time was 22,8. Main preoperative diagnoses were keratoconus (37%) and congenital glaucoma (20%). Graft failure percentage significantly changed (p=0.0185) between PK (59%) and DALK (46%) patients. Patients ≤5 years showed a higher percentage of graft failure (p=0.0008). Age is generally associated with a higher probability of graft failure (p<0.0001), but only in PK patients it reaches the statistical significance (p<0.001).


Our findings suggest that children older than 5 years show a significant better graft outcome and that in children DALK seems to offer greatest benefits in terms of risk of failure.

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