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Evaluation of safety and efficacy of nepafenac eye drops and its comparision with prednisolone eye drops in ocular inflammation in patients following cataract surgery

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Session Details

Session Title: Special Cases I

Session Date/Time: Sunday 06/09/2015 | 14:30-16:00

Paper Time: 15:10

Venue: Room 10

First Author: : V.Rajput INDIA

Co Author(s): :    P. Naik   U. Usgaonkar   S. Bhalsing              

Abstract Details

Purpose:

Cataract surgery being an invasive process, requires incision, cutting of ocular tissue and intraocular tissue manipulation,which leads to disruption of the blood-aqueous barrier with cellular infiltration leading to intraocular inflammation. Glucocorticoids suppress the production of inflammatory chemical mediators, but the anti-inflammatory effect is accompanied at times by interference with cellular wound healing in the post-operative period, aggravate infection and have a tendency to raise intraocular pressure. This study evaluates the efficacy of Nepafenac eye drops (0.1%) in ocular inflammation following cataract surgery & monitor its adverse effects, if any and to compare its anti-inflammatory properties with Prednisolone eye drops.

Setting:

Goa Medical College, Tertiary eye care center, Goa, India.

Methods:

In this randomized, comparative study patients who underwent cataract surgery with intraocular lens implantation were divided randomly in two groups-Group A [100 CCPE (clear corneal phacoemulsification), 50 SICS (small incision cataract surgery)] received nepafenac eye drops & group B (100 CCPE, 50 SICS) received prednisolone eye drops for six weeks. The patients were examined on day 1, 1st , 3rd & 6th week for signs of inflammation. To test the stastical significance, z –test of significance was used.

Results:

In group A with CCPE, 24% of patients with no cells on day 1, improved to 78% by week 1 and 95% by 3rd week. 76% of patients with cells on day 1 reduced to 5% by week 3. In group B with CCPE, 31% of patients with no cells on day 1, improved to 58% by week 1 and 89% by 3rd week. 69% of patients with cells on day 1 reduced to 11% by week 3. None of the patients had cells at the end of 6th week. Similar results were seen in patients with SICS.

Conclusions:

In this study we proved that Nepafenac eye drops was equally efficacious as prednisolone and no side-effects of nepafenac were noted . Hence, to conclude in patients with uneventful cataract surgery, nepafenac eye drops produce similar anti-inflammatory effect as that of prednisolone eye drops with additional advantage of better pain relief and without the side-effects associated with steroids.

Financial Interest:

NONE

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