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The risk of primary open angle glaucoma and glutathione STransferase M1 and T1 polymorphism among Egyptians

Poster Details

First Author: A.saif EGYPT

Co Author(s):    H. Abdel Rasool   S. Nowier   M. Gheith   S. Ismail     

Abstract Details

Purpose:

The aim of this study was to determine the effects of genetic polymorphisms of glutathione S transferase GSTM1 and GSTT1 on the risk of POAG in an Egyptian population.

Setting:

Case–control study in Research Institute of Ophthalmology and Fayoum University Teaching Hospital

Methods:

We compared the prevalence of GSTT1 and GSTM1 deletion genotypes, which were determined by multiplex polymerase chain reaction, in 32 patients with primary open angle glaucoma to 16 age, sex, and ethnically matched controls.

Results:

The GSTM1 positive genotype had an increased risk of developing POAG (p< 0.05, OR 4.681, 95% CI 1.190 – 18.412). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p< 0.05, OR 4.700, 95% CI 0.959 – 23.033).

Conclusions:

The GSTM1 positive genotype or the combination of both GSTM1 positive and GSTT1 null genotypes may be associated with the increased risk of development of POAG in the Egyptian population. The overall results indicate a possible variable association between various GSTT1 and GSTM1 genotypes and primary open angle glaucoma. Decreased GST function might interfere with the metabolism of oxidative intermediates and exacerbate the direct or indirect damaging effects of oxidative stress on the optic nerve. It is possible that these GST polymorphisms may be risk factors for primary open angle glaucoma [ FINANCIAL DISCLOUSRE: NONE

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