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Re-Perg: a new procedure for electrophysiological diagnosis of glaucoma that may improve Perg specificity

Poster Details

First Author: A.Mavilio ITALY

Co Author(s):    D. Sisto   N. Cardascia   P. Ferreri   G. Alessio     

Abstract Details

Purpose:

A significant variability of the 2nd harmonic (2ndH) phase of steady-state Pattern Electroretinogram (PERGss) in intrasession re-test has been recently described in glaucoma patients; such variability has not been found in healthy subjects. To evaluate reliability of phase variability in re-test (procedure called RE-PERG) in presence of cataract, which is known to affect standard PERG, we tested this procedure in glaucomatous patients (GP), normal controls (NC) and cataract patients (CP).

Setting:

Eye Clinic, University of Bari 'Aldo Moro'

Methods:

The procedure was performed on 50 GP, 35 NC and 27 CP. All subjects were examined with RE-PERG and PERGLA (PERG optimized for glaucoma), and also with spectral-domain coherence tomography (SD-OCT) and standard automated perimetry (SAP). Standard deviation of phase (SDph) and amplitude value (Amp) of 2ndH were correlated, by means of one-way ANOVA and Pearson correlation, with mean deviation (MD) and pattern standard deviation (PSD) assessed by SAP and Retinal Nerve Fiber Layer (RNFL) and ganglion cell complex (GCC) assessed by SD-OCT. Receiver operating characteristics (ROCs) were calculated in cohort populations with and whitout cataract.

Results:

SDph of 2ndH was significantly higher in GP with respect to NC (p < 0.001) and CP (p < 0.001) and it was correlated with RNFL (r = -0,5; p < 0.001) and GCC (r = -0,59; p <0.001) defects in GP. ROCs evaluation showed higher specificity of RE-PERG (88.85%; area under the curve 0,88) with respect to PERGLA (57.21%: area under the curve 0,72) in CP.

Conclusions:

RE-PERG may improve specificity of PERGss in clinical practice in the discrimination of glaucoma patients. FINANCIAL DISCLOUSRE: NONE

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