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Dual Scheimpflug analysis in relatives of patients with familial keratoconus

Poster Details

First Author: S.Blazaki GREECE

Co Author(s):    G. Kymionis   K. Tsoulnaras   A. Giarmoukakis   M. Grentzelos   M. Tsilimbaris  

Abstract Details

Purpose:

To analyze corneal topography of relatives of familial keratoconus patients in Crete, to detect suspect corneal patterns and differentiate them from normal.

Setting:

Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete, Greece Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Crete, Greece Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA

Methods:

In this prospective, comparative, blind study, we investigated familial forms of KC by screening relatives (both eyes) of KC patients with familial keratoconus; a control group was also recruited, including candidates of refractive surgery. All participants underwent corneal imaging with Dual-Scheimpflug technology. Qualitative (via colored maps) and quantitative (via indices) analyses were performed. Statistical comparisons were applied between relatives and controls.

Results:

Dual Scheimpflug Analyzer established a frequency of familial-KC of 11.6%(25 out of 216 KC patients). 85 relatives was recruited(51 clinical-KC and 34 healthy), as well as a control group (53 healthy). Two topography patterns were overexpressed in 53% of first-degree relatives with no-KC: the asymmetric bow-tie with inferior steepening and the inferior steepening. The quantitative analysis of these suspect patterns showed that 7 out of 12 indices were significantly different compared to control-group. Receiver-operating-characteristic-curves indicated that inferior-superior index was the most reliable in distinguishing suspect from normal corneas, with a maximum Area-Under-the-Curve of 0.942 and a cut-off value of 0.82D.

Conclusions:

Our study showed high frequency of familial KC in Crete (11.6%). Dual Scheimpflug technology enables the detection of suspect corneal patterns among relatives of patients with familial KC, while effectively discriminating them from normal by means of a series of KC-related indices FINANCIAL DISCLOUSRE: NONE

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