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A novel drug-eluting intraocular lens

Poster Details

First Author: L.Lamprogiannis GREECE

Co Author(s):    A. Karamitsos   V. Karagkiozaki   S. Logothetidis   S. Dimitrakos   I. Tsinopoulos  

Abstract Details

Purpose:

Design and fabrication of a prototype intraocular drug delivery system consisting of a three-piece acrylic lens and a biocompatible drug eluting thin film on the surface of the lens. Assessment of physical properties, drug release study, sterilization process and in vitro toxicity study.

Setting:

2nd University Ophthalmology Clinic, Aristotle University of Thessaloniki, Greece Laboratory for Thin Films, Nanosystems and Nanometrology, Physics Department of Aristotle University of Thessaloniki, Greece

Methods:

A biodegradable organic polymer thin film was developed by the method of spin coating on the surface of 3-piece intraocular lenses. The IOL-thin film systems were studied with the use of AFM and ellipsometry. Release rate of dexamethasone was studied for a period of ten weeks following sterilization with the use of UV radiation. In vitro toxicity study was conducted.

Results:

The films formed nanopores, in agreement with previous findings. The ellipsometry study showed transparent samples. The study of drug release demonstrated a smooth release for the first 6 weeks. Sterilization process was successful and no toxicity was recorded during the in vitro study

Conclusions:

In vivo studies may confirm these promising results and open a path for commercial application of this technique. FINANCIAL DISCLOUSRE: NONE

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