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The effects of oestrogen and progesterone on cornea in different periods of women life

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Session Details

Session Title: Cornea
Session Date/Time: Sunday 28/02/2016 | 08:30-11:00
Paper Time: 08:30
Venue: MC2 Room
First Author: : A.Kilavuzoglu TURKEY
Co Author(s): :    C. Cosar   I. Bildirici   O. Cetin        

Abstract Details


We investigated the effects of oestrogen and progesterone on corneal thickness, curvature and biomechanics in different periods of women life.


Acibadem University School of Medicine, Ophthalmology Department, Istanbul, Turkey


According to the hormonal status, the study included 5 groups of women: 15–25 year olds, > 25 year olds, pregnant, lactating, menopause. The women’s blood oestradiol and progesterone levels were measured. All the patients underwent a full ophthalmologic examination including corneal thickness and corneal topography measurements perfomed by Pentacam corneal topography and the evaluation of biomechanical properties of the cornea performed by Ocular Response Analyzer. More than twenty five year olds group was evaluated three times during menstrual cycle: preovulatory, ovulatory, and postovulatory.


Oestrogen and progesterone levels, spherical equivalent refraction, intraocular pressure (IOP), Goldmann correlated IOP (IOPg), corneal compansated IOP (IOPcc), corneal resistance factor, anterior corneal flat keratometry, anterior chamber volume, anterior chamber angle, anterior chamber depth were statistically different between the groups (P < 0.05). There was a significant correlation between oestrogen and IOP and anterior chamber volume; and between progesterone and IOP, IOPg, and IOPcc (P < 0.05). There was a statistically significant difference between preovulatory, ovulatory and postovulatory phase measurements in > 25 year olds regarding posterior corneal steep keratometry (P < 0.05).


The blood levels of oestrogen and progesterone affected IOP, but there wasn’t any constant effect of oestrogen and progesterone on corneal biomechanical properties and corneal topographic parameters. The changes in oestrogen and progesterone levels may induce formation or progression of an ectatic corneal disease, if there is an underlying corneal pathology.

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