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One day topical nepafenac pretreatment inhibits the elevation of the total prostaglandin level caused by the femtosecond laser pre-treatment during femtosecond laser-assisted cataract surgeries

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Session Details

Session Title: Cataract II
Session Date/Time: Saturday 27/02/2016 | 08:30-11:00
Paper Time: 09:36
Venue: Trianti Room
First Author: : H.Kiss HUNGARY
Co Author(s): :    A. Takacs   K. Kranitz   G. Sandor   G. Toth   B. Gilanyi   Z. Nagy

Abstract Details


To determine, if a pretreatment with a topical non-steroidal anti-inflammatory drug (NSAID) prior to the femtosecond laser-assisted cataract surgery (FLACS) prevents the prostaglandin level rise following the femtolaser pretreatment.


Semmelweis University, Department of Ophthalmology, Budapest, Hungary Semmelweis University, Department of Medical Chemistry, Budapest, Hungary


Thirty-six patients with clinically significant senile cataract and without any concomitant general or ophthalmic disease were enrolled into the three age-matched groups of our study. The first group of patients underwent traditional phacoemulsification (control group), the patients of the second and third group underwent FLACS. The patients of the third group received topical 0.1% nepafenac pretreatment for one day prior the surgery. In all groups before the phacoemulsification part of the cataract surgery approximately 110 ųL of aqueous humor was collected, and by the help of enzyme immunoassay (EIA) total prostaglandin concentration of the samples was evaluated.


The mean of the total prostaglandin concentrations of the aqueous humor samples was 208.8±140.5 pg/mL in patients of the control group, 1449.1±1019.7 pg/mL in the FLACS group (p>0.001), and 92.2±51.7 pg/mL in the pretreated FLACS group (p>0.001 compared to FLACS; p>0.01 compared to the control group), respectively.


FLACS surgery increases intracameral total prostaglandin concentration. However, using a topical NSAID drop for one day preoperatively, the total prostaglandin rise int he anterior chamber is inhibited completely. Our study raises the possibility, that NSAID pretreatment may be routinely administered before FLACS, to diminish the odds of the intra- and postoperative prostaglandin related complications.

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