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Effects of a Dorzolamide/Timolol fixed combination on diurnal intraocular pressure, heart rate, blood pressure and ocular perfusion pressure in normal-tension glaucoma

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Session Details

Session Title: Special Cases
Session Date/Time: Friday 26/02/2016 | 08:30-10:00
Paper Time: 08:42
Venue: MC3 Room
First Author: : N.Lee SOUTH KOREA
Co Author(s): :                  

Abstract Details


To evaluate the effects of a dorzolamide-timolol fixed combination (DTFC) on intraocular pressure (IOP), heart rate (HR), blood pressure (BP), ocular perfusion pressure (OPP), and diastolic ocular perfusion pressure (DOPP) in patients with normal-tension glaucoma (NTG).


Hospital based.


A prospective, interventional, single-blind, single-center study was conducted. Patients with newly diagnosed NTG that had not been treated with a glaucoma medication in the most recent 4 weeks were analyzed. Patients were examined on day 1 (without medication) and week 4 (under medication). Baseline IOP, HR, systolic and diastolic BP, OPP, and DOPP were measured at 8:00 AM, 12:00 PM, and 4:00 PM. At week 4, IOP, HR, BP, OPP, and DOPP were measured at 10:00 AM and 8:00 PM as well.


After 4 weeks of DTFC treatment, IOP was significantly reduced at all time points (1.6 - 2.6 mmHg, P < 0.001), and the average IOP reduction was 14.4%. HR and systolic BP showed no statistically significant difference at all time points; however, diastolic BP was decreased significantly at 12:00 PM and 4:00 PM (P = 0.004 and 0.001). Diurnal OPP increased with statistical significance after DTFC (P = 0.043). Diurnal DOPP showed no statistically significant difference after DTFC.


DTFC has favorable effects on IOP and OPP and can be used without concerns of DOPP in patients with NTG.

Financial Disclosure:


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