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Relationship between size of area opaque by retrodots and higher-order aberration

Poster Details

First Author: H.Sasaki JAPAN

Co Author(s):    N. Mita   N. Hatsusaka   E. Shibuya   M. Sasaki   K. Sasaki   E. Kubo

Abstract Details


Retrodots (RD) mainly affect eyes among the elderly, sometimes causing deterioration of visual function. We examined the relationships among size of area opaque by RD and best corrected visual acuity (BCVA), refractive error, and high-order aberration (HOA).


Among the participants of Monzen Eye Study from 2006 to 2011, 74 eyes (age 70.3ḟ6.5 yrs) with RD were enrolled.


Subjects with ocular disease other than refractive error, and those with lens opacities of cortical cataract, nuclear cataract, or posterior subcapsular cataract, at grade1 or over (WHO classification system), and those with water clefts, were excluded. The opaque area of RD within 3mm and 6mm diameter of the pupil center, and light scattering intensities (LSI) in anterior adult nucleus, anterior embryo nucleus and central clear zone were measured from retro-illumination and slit images captured by anterior eye segment analysis system (EAS-1000, NIDEK) under maximum pupil dilation. Crystalline lens power (LP) was also determined. Ocular and internal total HOA, coma and spherical aberration in 4mm and 6mm diameter pupils were measured using wave front analyzer (KR9000PW, Topcon).


As area opaque by RD increased, BCVA deteriorated (r=0.649, p<0.01), LP decreased (r=0.239, p<0.05) and spherical equivalent showed progressive myopic shift (r=0.329, p<0.01). Opaque area of RD correlated with: internal total HOA (4mm: r=0.344, p<0.01, 6mm: r=0.508, p<0.01), coma aberration (4mm: r=0.305, p<0.05, 6mm: r=0.579?p<0.01) and negative spherical aberration (4mm: r=0.461, p<0.01, 6mm: r= 0.412, p<0.01). Although we found a significant correlation between increasing negative spherical aberration and area opaque by RD (4mm: r=0.533, p<0.01, 6mm: r= 0.473, p<0.01), no significant relationship was seen between RD area and ocular HOA, or coma aberration. Nor between RD area and LSI, or spherical equivalent and ocular HOA (total HOA, coma and spherical aberration).


Increased size of area opaque by RD caused deterioration of BCVA, myopic shift and increasing negative spherical aberration.

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