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First Author: K.Minami JAPAN
Co Author(s): Y. Maruyama M. Honbou J. Matsunaga K. Miyata
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Surface light scattering attributed to phase separation of nanometer-order water aggregates has been reported in AcrySof® (Alcon) intraocular lens (IOL). This has been addressed by optimizing the production process. The purpose of this in vitro experiment was to examine the incidence of surface light scattering using accelerated aging technique.
Miyata Eye Hospital, Miyazaki, Japan
Samples were conventional SA60AT and SN60WF made using the optimized production process. Of each model, 20 IOLs were aged accelerately for 0, 3, 5, 10, 15, and 20 years at 90 degree C in the BSS. Light scatterings on central 3mm diameter on the anterior surface of aged IOLs were measured with densitometry (CCT unit) in a Scheimpflug camera EAS-1000 (Nidek).
Mean surface light scattering of SA60AT was 17.6 ±3.1, 46.4 ±4.9, 58.3 ±9.2, and 83.0 ±4.5 CCT at 0, 5, 10, and 20 years aging, respectively with a significant increase (p < 0.001, Steel multiple test). Increasing rate was 3.17 CCT/year. Surface light scattering of SN60WF was 16.6 ±1.8, 16.4 ±2.0, 18.0 ±2.3, and 17.6 ±3.8 CCT, respectively. Linear regression was significant with increasing rate of 0.10 CCT/year.
The in vitro model using accelerated aging effectively stimulated increased surface light scattering in AcrySof IOL. This study demonstrated that the improved AcrySof IOL drastically suppressed an incidence of surface light scattering.
... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented