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Immunohistochemical expression of Fas ligand (FasL) and neprilysin (neutral endopeptidase/CD10) in keratoconus

Poster Details

First Author: H.Saad EGYPT

Co Author(s):    E. Hasby              

Abstract Details



Purpose:

The aim of this study was to investigate the immunohistochemical expression of Fas ligand (FasL) and neprilysin in keratoconic corneas in comparison to normal cadaver corneas to evaluate if such molecules play a role in the pathogenesis of keratoconus.

Setting:

This was an experimental comparative study enrolling 15 keratoconic corneas and 5 normal cadaveric corneas between January 1, 2012 and June 30, 2012.

Methods:

We studied the clinicopathological features of 15 cases of KCN and evaluated the expression of CD 68, Fas Ligand (FasL), and membrane metalloendopeptidase (CD10/Neprilysin) in the corneal specimens that were removed during penetrating keratoplasty and compared them to 5 cadaver control corneas.

Results:

Central KCN corneas showed higher expression of CD68, FasL and CD 10 than periphery and cadaver control corneas. CD 68 showed mainly stromal expression, while, both FasL and CD10 showed mainly epithelial expression and had the same distribution.

Conclusions:

Abnormal tissue degradation and chronic apoptosis may play a role in the disease and corneal epithelium may be the primary site in the pathogenesis of KCN.

Financial Disclosure:

NONE

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