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Daytime variations of tear osmolarity measurement in dry eyes patients

Poster Details

First Author: F.Yi?it TURKEY

Co Author(s):    Y. Evcimen   F. Kirik   A. Agachan        

Abstract Details


We have targeted primarily to show the variation of tear osmolarity during the daytime period in person with dry eyes and non dry eyes, secondary to evaluate of these variation relationship with Schirmer Test and Break-up Time (BUT).


SB Bak?rköy Dr. Sadi Konuk Training and Education Hospital, Ophthalmology Department, Istanbul, Turkey


New diagnosed 20 dry eye patients and 20 healty voluntary person similar age and gender included prospectively in this study. In addition to the full ophthalmic examination, it has done Schirmer Test and BUT test to all participants. Tear osmolarity measurements have done after pre-examination but in different day. The measurements have registered the measurements with TearLab Osmolarity System (TearLab Corporation, San Diego, CA, USA) every 3 hours within 8:00 AM and 5:00 PM. The results have evaluated statistically.


No statistically significant difference were found between mean age, gender of dry eye syndrome (DES) and control groups (p>0.05). The mean measurement of Schirmer Test and BUT of DES group were statistically significantly lower than control group (p=0.0001). The mean measurement of tear osmolarity 8:00 AM, 11:00 AM, 2:00 PM and 5:00 PM of DES group were statistically significantly higher than control group (p=0.001, p=0.0001). No statistically significant difference were found between groups and in group of DES and control groups (p>0.05).


In day time variation of the tear osmolarity study result in dry eye patients and healthy subjects, we did not determine significant change in both groups. As a secondary result, we have concluded that there is no difference among tear osmolarity, Shirmer and BUT tests in diagnosis of DES.

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