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First Author: C.Altan TURKEY
Co Author(s): A. Demircan O. Osmanbasoglu B. Satana B. Basarir A. Agca A. Demirok
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To compare subfoveal choroidal thickness (SFCT) between patients with nanophthalmos and age-matched controls.
Istanbul Beyoglu Eye Training and Research Hospital.
This prospective, cross-sectional and comparative study include 31 eyes of 31 patients with nanophthalmos and 31 eyes of 31 healty subjects (control group). Subfoveal choroidal thickness and central macular thicness (CMT) were measured with spectral domain optical coherence tomography (SD-OCT) (Spectralis, Heidelberg Engineering) with enhanced depth imaging (EDI) and fast macular thickness mode. Also, all participants underwent a standardised ocular examination including central corneal thickness (CCT), anterior chamber depth (ACD), refractive errors measurements.
Mean SFCT in the nanophthalmic eyes and in the control eyes were 551.3ḟ87 ṁm and 330.5ḟ46 ṁm respectively (p< 0.001). Mean CMT was 331.9ḟ78 in the nanophthalmic eyes and 268.9ḟ24 ṁm in the control group (p<0.001). Mean AL, ACD, CCT values were respectively 18.8ḟ1.5 mm, 2.42ḟ0.4 mm and 577,2ḟ32 ṁm in nanophthalmic eyes and 23.1ḟ0.6 mm, 3.16ḟ0.3 mm and 532ḟ29 ṁm in the control group (p<0.001). Mean best corrected visual acuity (BCVA) was 0.4ḟ0.28 logMAR in nanophthalmic eyes and 0.00ḟ0.02 logMAR in the control group (p<0.001). Mean spherical equivalent (SE) in the nanophthalmic eyes and conrol eyes were +10.6ḟ3 and +0.53ḟ0 D respectively (p<0.001).There were negative correlation in between SFCT with AL (r= -0.836, p<0.001), ACD (r= -0.597, P<0.001) and BCVA (r=-0,691, p<0.00) in all study population. The SFCT was significantly correlated with the CCT (r=0,471, p<0.001) and CMT (r=0.585, p<0.001), SE (r=0,836, p<0.001).
SFCT was significantly higher in the nanophthalmic eyes. Further studies are needed to explain the importance of SFCT for understantanding the pathophysiology.