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The influence of 3% trehalose solution on the quality of vision in patients after refractive surgery

Poster Details

First Author: E.Mrukwa-Kominek POLAND

Co Author(s):    A. Rogowska-Godela   B. Buba?a-Stachowicz   M. Sarnat   P. Gosciniewicz     

Abstract Details


The assessment of the tear film stability, corneal epithelium condition, optical aberrations as a function of vision in patients after photorefractive keratectomy


Department of Ophthalmology, Medical University of Silesia, University Hospital No5, Katowice, Poland


Photorefractive keratectomy was performed in 40 patients in 80 eyes divided in two groups: group I - 40 eyes treated with a solution of 3% trehalose and group II - treated with the preservative free artificial tears. Both groups were statistically consistent as to sex, age and refractive errors corrected. All patients were examined: 7 days, 3 weeks, 6 weeks and three months after surgery. The following parameters were assessed: visual acuity without correction, corneal fluorescein staining test, fluorescein tear film break-up time (fTBUT), mean spherical equivalent, corneal topography keratometric values, optical aberrations (RMS, HoA) and images in confocal microscopy


There were no statistically significant differences between groups in postoperative visual acuity, mean spherical equivalent, mean keratometric values, and the corneal aberration. Statistically significant differences were found in evaluating corneal fluorescein staining test and fTBUT in favor of the group I 3 weeks after surgery. Delayed epithelialization was not observed in group I while 2 patients (3eyes) in group II experienced delayed epithelialization longer than 7 days after surgery


The use of 3% trehalose solution after photorefractive keratectomy is a reasonable due to the efficient regeneration of the corneal epithelium and tear film stability, especially in the early postoperative period.

Financial Disclosure:

... receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented.

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