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Comparison of anterior corneal aberrations three years after LASIK and photorefractive keratectomy

Poster Details

First Author: S.Patel USA

Co Author(s):    J. McLaren              

Abstract Details



Purpose:

To compare anterior corneal aberrations in eyes through three years after non-wavefront-guided LASIK and photorefractive keratectomy (PRK).

Setting:

Prospective, parallel, observational study of patients attending the refractive surgery service at Mayo Clinic, Rochester, Minnesota.

Methods:

Forty-two eyes of 21 patients received LASIK, and 40 eyes of 20 patients received PRK, for myopia or myopic astigmatism. Eyes were examined before and at 1 and 3 years after surgery. High-order aberration (HOA) wavefront errors from the anterior corneal surface were derived from corneal topograms and were expressed as Zernike polynomials through the sixth order across 4 mm- and 6 mm-diameter optical zones. Differences between treatments were assessed by using generalized estimating equation models to account for any correlation between fellow eyes of the same subjects.

Results:

Manifest refractive error (spheroequivalent) was -3.7 ±1.6 D (mean ±sd; range, -1.25 to -7.25 D) before LASIK and -3.4 ±1.5 D (range, -0.75 to -6.25 D) before PRK (p=0.42). Across a 4 mm-diameter optical zone, total HOAs before LASIK (0.14 ±0.05 ṁm) did not differ from total HOAs before PRK (0.14 ±0.07 ṁm; p=0.85), with no differences between specific aberrations. At 1 year, total HOAs were higher after LASIK (0.19 ±0.08 ṁm) than after PRK (0.16 ±0.11 ṁm, p=0.008); although a similar trend was evident at 3 years (LASIK, 0.18 ±0.05 ṁm; PRK, 0.16 ±0.05 ṁm), the difference was not significant (p=0.06; minimum detectable difference, 0.03 ṁm). Across a 6 mm-diameter optical zone, total HOAs before LASIK (0.47 ±0.20 ṁm) did not differ from total HOAs before PRK (0.42 ±0.12 ṁm; p=0.56), with no differences between specific aberrations. At 1 year, total HOAs were higher after LASIK (0.69 ±0.19 ṁm) than after PRK (0.62 ±0.27 ṁm, p=0.03); although a similar trend was evident at 3 years (LASIK, 0.69 ±0.20 ṁm; PRK, 0.62 ±0.15 ṁm), the difference was not significant (p=0.14; minimum detectable difference, 0.12 ṁm).

Conclusions:

For similar myopic treatments, LASIK induces slightly more high-order aberrations than PRK after non-wavefront-guided treatment.

Financial Disclosure:

NONE

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