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First Author: S.Patel USA
Co Author(s): J. McLaren
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To compare anterior corneal aberrations in eyes through three years after non-wavefront-guided LASIK and photorefractive keratectomy (PRK).
Prospective, parallel, observational study of patients attending the refractive surgery service at Mayo Clinic, Rochester, Minnesota.
Forty-two eyes of 21 patients received LASIK, and 40 eyes of 20 patients received PRK, for myopia or myopic astigmatism. Eyes were examined before and at 1 and 3 years after surgery. High-order aberration (HOA) wavefront errors from the anterior corneal surface were derived from corneal topograms and were expressed as Zernike polynomials through the sixth order across 4 mm- and 6 mm-diameter optical zones. Differences between treatments were assessed by using generalized estimating equation models to account for any correlation between fellow eyes of the same subjects.
Manifest refractive error (spheroequivalent) was -3.7 ±1.6 D (mean ±sd; range, -1.25 to -7.25 D) before LASIK and -3.4 ±1.5 D (range, -0.75 to -6.25 D) before PRK (p=0.42). Across a 4 mm-diameter optical zone, total HOAs before LASIK (0.14 ±0.05 ṁm) did not differ from total HOAs before PRK (0.14 ±0.07 ṁm; p=0.85), with no differences between specific aberrations. At 1 year, total HOAs were higher after LASIK (0.19 ±0.08 ṁm) than after PRK (0.16 ±0.11 ṁm, p=0.008); although a similar trend was evident at 3 years (LASIK, 0.18 ±0.05 ṁm; PRK, 0.16 ±0.05 ṁm), the difference was not significant (p=0.06; minimum detectable difference, 0.03 ṁm). Across a 6 mm-diameter optical zone, total HOAs before LASIK (0.47 ±0.20 ṁm) did not differ from total HOAs before PRK (0.42 ±0.12 ṁm; p=0.56), with no differences between specific aberrations. At 1 year, total HOAs were higher after LASIK (0.69 ±0.19 ṁm) than after PRK (0.62 ±0.27 ṁm, p=0.03); although a similar trend was evident at 3 years (LASIK, 0.69 ±0.20 ṁm; PRK, 0.62 ±0.15 ṁm), the difference was not significant (p=0.14; minimum detectable difference, 0.12 ṁm).
For similar myopic treatments, LASIK induces slightly more high-order aberrations than PRK after non-wavefront-guided treatment.