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Environmental influences on the degradation of intraocular lenses (IOLs) in in vitro conditions

Poster Details

First Author: P.Chaniecki POLAND

Co Author(s):    E. Stodolak-Zych   M. R?kas           

Abstract Details


To evaluate in in vitro conditions degradation of different (hydrophobic and hydrophilic) intraocular lenses (IOL)


Department of Opthalmology, 5th Military Hospital with Policlinic, Krakow, Poland; AGH - University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, Krakow, Poland; Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland


Degradation of the IOLs was conducted in a two-step experiment. At the first step the IOLs were incubated in BSS solution at 95oC. The degradation time was calculated according to ISO 11979-5:2006 After the IOLs were immersed for 24h in 1 % chicken albumin solution . Progress in degradation of the single IOL was observed by physicochemical methods. Surface state of the materials was characterised by the dynamic method of wetting angle determination (DSA 10 Kruss, Germany). As the measurement liquid ultra high quality (UHQ) water was used. Free surface energy (ITF) was determined by the Owens-Wendt method using double-distilled UHQ water and diiodomethane (Aldrich Chemical Co.). Microstructure of their surface was investigated using an optical microscope (Nicon ZT400)


After 28 days of the in vitro incubation which corresponds to the presence of 5 years in vivo conditions surface of both types of the IOLs: hydrophobic and hydrophilic (8 types) become more hydrophilic. Only the IOL covered with modifying layer showed more hydrophobic properties after 5 years degradation. Results of the surface free energyITF measurements confirmed this observation i.e. dispersion component was much higher. After this time of protein (albumin) adsorption of IOL’s surfaces wettability increases. It is supposed, that such surfaces are more prone to adhesion of cells onto the IOLs . Degradation process was observed in all examined IOLs.


The presented method can be used for approximation of the degradation behaviour of IOLs. The results showed that all materials changed in vitro conditions, and regardless of their original character i.e. hydrophilic or hydrophobic they were covered by the protein layer, which is the first step to the cells adhesion.

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