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In vivo “histology” of iridocorneal endothelial syndrome (ICE) by confocal microscopy (CM)

Poster Details

First Author: C.Malhotra INDIA

Co Author(s):    A. Jain              

Abstract Details


To describe the microstructural characteristics of corneal endothelium in Iridocorneal Endothelial Syndrome (ICE) by in vivo confocal microscopy(CM)


Tertiary care ophthalmology centre in North India


In vivo CM using the HRT III Rostock Cornea module was done for patients having clinical features consistent with a diagnosis of ICE syndrome.


Three types of alterations were visible at the leve of the endothelium: a) epitheloid like endothelial cells showing pleomorphism and prominent, nonhomogenous, diversely shaped nuclei , b) endothelial cells with poorly delieanated borders having bright, evenly distributed prominent hyper-reflective nuclei c) foci of endothelial cells showing “light dark reversal” ie dark cell centre surrounded by bright cell borders (these abnormal cells appeared to be surrounded by normal looking endothelium)


In vivo CM is a powerful tool to image the corneal endothelial changes in ICE syndrome. This can be specially useful in establishing the diagnosis in those cases where the clinical picture may overlap with other corneal endothelial disorders

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