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First Author: H.Bayhan TURKEY
Co Author(s): S. Aslan Bayhan E. Muhaf?z ?. Can
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To compare the central corneal thickness (CCT) in patients with diabetes mellitus (DM) and healthy control subjects and to evaluate the association between diabetic parameters and CCT.
Bozok University Faculty of Medicine, Yozgat, Turkey.
In this prospective study, 48 eyes of 48 diabetic patients and 48 eyes of 48 control subjects were evaluated. Diabetic patients and control group were compared in terms of CCT measured by spectral domain optical coherence tomography (RTVue,Optovue). The effects of age, sex, blood glucose concentration, percentage of hemoglobin A1c (HbA1c), insulin usage,presence of diabetic retinopathy, and duration of DM on CCT were assessed
The CCT was significantly greater in diabetic group (545.13ḟ34.01ṁm) compared with control group (530.73ḟ22.82ṁm) (P=0.004). CCT was moderately correlated with HbA1c (r=0.558, P<0.01) and weakly correlated with blood glucose (r=0.359, P=0.047). Multiple regression analysis evaluating the effects of age, sex, blood glucose concentration, HbA1c, insulin usage,presence of diabetic retinopathy, and duration of DM on CCT showed that HbA1c value was the only significant factor associated with increased CCT.
CCT of diabetic patients is increased that is related to HbA1c value. Further studies are required to establish whether interventions to affect HbA1c value may reduce CCT.