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Comparison of the effects of prostoglandin analogues on intraocular pressure, central corneal thickness and anterior chamber depth

Poster Details

First Author: F.Yilmaz TURKEY

Co Author(s):    H. Serdarogullari   Y. Malkoc   M. Elcioglu        

Abstract Details



Purpose:

To evaluate and compare the effects of latanoprost, travoprost and bimatoprost on intraocular pressure, central corneal thickness and anterior chamber depth

Setting:

Okmeydani Training and Research Hospital,Istanbul, Turkey

Methods:

A total of 65 eyes of 65 patients with primary open angle glaucoma or ocular hypertension were included in the study. Intraocular pressure was measured with applanation tonometry; central corneal thickness and anterior chamber depth were measured with Pentacam in 30 eyes treated with latanoprost ophthalmic solution 0.005%, in 24 eyes treated with travoprost ophthalmic solution 0.004%, and in 20 eyes treated with bimatoprost ophthalmic solution 0.03%. The measurements were taken at the initial diagnosis and at 6 months interval for 2 years

Results:

The mean age was 57.10 ±8.01 years in latanoprost group, 57.25 ±7.89 years in travoprost group, and 57.09 ±9.65 years in bimatoprost group. The reduction of intraocular pressure in latanoprost, travoprost, and bimatoprost groups was 6.87 ±2.11, 7.04 ±2.18, and 7.45 ±1.86 mmHg, respectively (P<0.001). A statistically significant reduction in central corneal thickness was found in all three groups (P<0.005). The reduction of central corneal thickness was 10.30 ±11.09, 8.46 ±5.21, and 7.36 ±6.41 ṁm, respectively. Although anterior chamber depth was reduced in latanoprost group and increased in travoprost and bimatoprost groups, these changes were not statistically significant (P>0.05). Also, there were no statistically significant differences in the change analysis of all parameters between the groups (P>0.05)

Conclusions:

Prostaglandin analogues are found to have similar intraocular pressure lowering effects. Besides, they result in reduction of central corneal thickness and have no effect on anterior chamber depth in 2-years follow-up. No difference was observed between the three groups in all parameters. Further studies are needed to support these outcomes

Financial Disclosure:

NONE

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