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Comparison of the effects of prostoglandin analogues on intraocular pressure, central corneal thickness and anterior chamber depth

Poster Details

First Author: F.Yilmaz TURKEY

Co Author(s):    H. Serdarogullari   Y. Malkoc   M. Elcioglu        

Abstract Details


To evaluate and compare the effects of latanoprost, travoprost and bimatoprost on intraocular pressure, central corneal thickness and anterior chamber depth


Okmeydani Training and Research Hospital,Istanbul, Turkey


A total of 65 eyes of 65 patients with primary open angle glaucoma or ocular hypertension were included in the study. Intraocular pressure was measured with applanation tonometry; central corneal thickness and anterior chamber depth were measured with Pentacam in 30 eyes treated with latanoprost ophthalmic solution 0.005%, in 24 eyes treated with travoprost ophthalmic solution 0.004%, and in 20 eyes treated with bimatoprost ophthalmic solution 0.03%. The measurements were taken at the initial diagnosis and at 6 months interval for 2 years


The mean age was 57.10 ±8.01 years in latanoprost group, 57.25 ±7.89 years in travoprost group, and 57.09 ±9.65 years in bimatoprost group. The reduction of intraocular pressure in latanoprost, travoprost, and bimatoprost groups was 6.87 ±2.11, 7.04 ±2.18, and 7.45 ±1.86 mmHg, respectively (P<0.001). A statistically significant reduction in central corneal thickness was found in all three groups (P<0.005). The reduction of central corneal thickness was 10.30 ±11.09, 8.46 ±5.21, and 7.36 ±6.41 ṁm, respectively. Although anterior chamber depth was reduced in latanoprost group and increased in travoprost and bimatoprost groups, these changes were not statistically significant (P>0.05). Also, there were no statistically significant differences in the change analysis of all parameters between the groups (P>0.05)


Prostaglandin analogues are found to have similar intraocular pressure lowering effects. Besides, they result in reduction of central corneal thickness and have no effect on anterior chamber depth in 2-years follow-up. No difference was observed between the three groups in all parameters. Further studies are needed to support these outcomes

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