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First Author: C.Sng SINGAPORE
Co Author(s): J. Allen M. Nongpiur T. Aung
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To determine the ocular biometric and demographic factors associated with iris parameters in Singaporean Chinese persons from a population-based sample.
Singaporean Chinese persons from a population-based sample
Subjects were participants in the Singapore Chinese Eye Study, a population-based cross-sectional study of eye disease. Anterior segment optical coherence tomography images were analysed using customized software to measure iris thickness at 750?m from the scleral spur (IT750), iris area (I-Area) and iris curvature (I-Curv). Regression analyses were performed to assess the association between iris measurements with a range of demographic and ocular variables. The contribution of each independent variable to the iris parameter of interest was sequentially determined using a stepwise selection algorithm.
We included 1473 participants with a mean age of 57.7 + 8.68 years, and 50.6% were men. The mean IT750, I-Area and I-Curv were 0.46ḟ0.10 mm, 1.49ḟ0.24 mm2 and 0.25ḟ0.13 mm respectively. Statistical regression models including a range of demographic and ocular parameters explained 60.2%, 42.1% and 36.6% of the variability in I-Curv, IT750 and I-Area respectively. Age, gender, axial length and anterior chamber width were poor correlates of iris measurements (partial R-square < 0.10). Angle opening distance at 750?m from the scleral spur (AOD750) was the single factor most strongly associated with I-Curv, and explained 46.5% of its variation.
A significant proportion of the variation in iris area, curvature and thickness was not explained by other ocular and demographic parameters. Iris curvature was strongly associated with angle width, and of all parameters investigated, AOD750 was most highly correlated with iris curvature.