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The suppressive effect of topical beta-adrenergic receptor antagonists on basophil activation in glaucoma patients

Poster Details

First Author: G.Shemesh ISRAEL

Co Author(s):    E. Rosenfeld   S. Kurtz   M. Lazar   S. Kivity   S. Langier  

Abstract Details



Purpose:

To evaluate the type of hypersensitivity reaction induced by Brimonidine 0.5%, Timolol 0.2%, and its combination using the basophil activation test (Basotest) in patients who had a hypersensitivity reaction to Brimonidine 0.5% and compared them to healthy individuals.

Setting:

ṗ Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Ġ Allergy and Immunology Internal Medicine Division, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Methods:

Peripheral blood was drawn from eight patients with a proven hypersensitivity to Brimonidine, and 6 healthy individuals. Basophil activation was identified by the expression of the activation molecule CD63 in high IgE cells (CD63+IgE high+). Basophil activation was tested following exposure to either Brimonidine, Timolol or its combination (combigan).

Results:

In healthy individuals there was a statistically significant difference in the percentage of CD63 activation when comparing Combigan (0.87%) to Timolol (2.27%), (p= 0.012) and Combigan (0.87%) to Alphagan (2.58%) (p=0.017). In the hypersensitive group, statistical significance was also found when comparing Combigan (0.81%) to Timolol (1.84%) (p=0.043), and almost statistical significance between Combigan (0.81%) to Alphagan (2.45%) (p=0.068).

Conclusions:

Based on the suppression of basophil activation drawn from both patients with a known hypersensitivity to Brimonidine, and healthy individuals, it is proposed that ß-blockers clinical effect is most likely pharmacological or physiological.

Financial Disclosure:

NONE

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